Moderna vaccine booster ‘effective against Covid variants in trials’

Moderna’s tweaked coronavirus vaccine has been found to neutralise both the Brazil and South Africa variants in laboratory trials.

The company behind the jab announced that a single dose of one of its vaccines given as a booster to previously vaccinated people increased neutralising antibody titer responses against SARS-CoV-2 and both the South Africa and Brazil variants.

The currently authorised Moderna Covid-19 vaccine is mRNA-1273 which was developed to protect against the ancestral strain of the virus first identified in Wuhan, China, while mRNA-1273.351 was developed to protect against the B.1.351 virus first identified in South Africa.

Moderna said a booster dose of mRNA-1273.351 achieved higher neutralising antibody titers against the South Africa variant than a booster dose of mRNA-1273.

The initial data is from a study involving 40 people.



It comes as ministers, health chiefs and government scientists are stepping up preparations for an autumn booster vaccination campaign to protect against a third wave of coronavirus.

Vaccines minister Nadhim Zahawi said scientists are looking at a range of options, including new jabs to protect against variants or mixing the types of injections given, so if a patient had AstraZeneca for their initial doses they could be given Pfizer as a booster.

“We want them to be able, if they need to, from September onwards to boost those that are most vulnerable,” Mr Zahawi said.

The Government has already ordered 60 million doses of the Pfizer vaccine in preparation for a booster campaign.

Mr Zahawi told Sky News: “Pfizer is one option, we’re going to give them an AstraZeneca option, we’re working with the team on a vaccine variant.

“Clinicians haven’t yet made the decision when they will need to boost, whether to give more immunity to the most vulnerable, to increase the durability of the protection or to deal with the variant.

“When they decide, I want to give them as much optionality, as many vaccines that were, then they will make those choices.”

England’s deputy chief medical officer Professor Jonathan Van-Tam is conducting a clinical trial to look at “which vaccine delivers the best boost”, Mr Zahawi said.

(PA graphic) Credit: PA graphic

The Government has committed almost £30 million to improve vaccine testing capacity to help keep on top of the virus and any new variants.

Health Secretary Matt Hancock said testing facilities at Porton Down in Wiltshire are to be bolstered to help “future-proof” the country, with a £29.3 million boost confirmed for the expansion of the laboratories where scientists test existing and new vaccines against variants of concern.

Tests on blood samples can help scientists monitor the effectiveness of coronavirus vaccines.

Current testing capacity is 700 a week, but the Department of Health and Social Care (DHSC) said this will increase to 1,500 by January 2022 – backed with a previous £20 million investment – rising to 3,000 with the increased funding.

Mr Zahawi told BBC Breakfast the investment into Porton Down would “future-proof the vaccination programme for next year and the years beyond that, as we move from pandemic to endemic and deal with it in the way we would deal with the annual flu vaccination programme”.

Asked whether all over-50s will be offered a booster shot before winter, Mr Zahawi said “that decision hasn’t been made”.

(PA Graphics) Credit: PA Graphics

Professor Adam Finn, a member of the Joint Committee on Vaccination and Immunisation, said variants will be an “increasing problem going forward” so the investment is a positive development as there is a backlog of tests to be conducted.

He told Sky: “We’re all well aware that this has been a concern since the beginning of the year, when we first reported the emergence of this much more infectious variant in the UK, and we’ve been hearing in the news for weeks and months now about variants and other parts of the world – South Africa and Brazil and, most recently, India – but there is virus circulation going on throughout the world and in many of those places there’s no real testing of the viruses going on, so there’s certainly viral evolution happening.

“As more and more of the world’s population become immune to the virus through infection or through immunisation, the speed of that is likely to go up so it’s certainly a problem now and it’s likely to be an increasing problem going forward.”


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